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Novartis shares drop 11% on drug failure as biosimilar gap threatens $200 billion in savings

9/13/2026

A failed clinical trial wiped nearly $30 billion from Novartis's market value this week after shares fell 11% in a single session, erasing all the gains the stock had made since the start of the year.

The drug that failed, del-desiran, was being tested for a muscle-wasting disorder in what is called a late-stage study, meaning the final major round of testing before a company can ask regulators to approve a treatment for real-world use.

It was the second major setback for Novartis in just days.

Eight shareholders told Reuters that the del-desiran result raised questions about last year's $12 billion Avidity acquisition and the company's broader dealmaking approach.

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